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Recent Progress of Glycoproteins(peptides) from Edible/Medicinal Fungi by Dr. Cui Fengjie

 Glycoproteins are the polysaccharide-peptide or polysaccharide-protein complexes with the protein/polypeptide chains bound covalently and specifically with carbohydrate side-chains. Generally, glycoproteins have the different structures and bioactivity mechanisms compared with those of polysaccharides. The processes for elucidating the polysaccharide structure include the determination of the monosaccharide composition, glycosidic linkage configuration, glycosidic linkage position, monosaccharide sequence, even secondary and helical conformation. As for investigating the glycoprotein structure, the polysaccharide and protein/peptide chains are firstly elucidated, respectively. And the glycosylated site in the glycoprotein is also an important item to be determined. Polysaccharides and glycoproteins possibly have the significant difference of antitumor mechanisms. In most cases, polysaccharides exert their antitumor action through activating the host immune systems, while glycoproteins kill the tumor cells directly by arresting the cell cycle and/or inducing the apoptosis of tumor cells.

Dr Cui has isolated and purified several antitumor and hemagglutinatory glycoproteins from edible fungi such as Grifola frondosa and Hericium erinaceus. These glycoproteins are rich in ¦Â-sheet predominant and hermo-unstable proteins, which have the novel structures compared to the known proteins in the currently known databases such as NCBI. Theses glycoproteins increased the expression levels of p53, Bad, Bax, Caspase 8, Caspase 3 genes and decreased the expression levels of CDK4,Bcl 2,PI3K,Akt genes in SGC-7901 cells to relealize its induction of the cells apoptosis.

Our researches are funded by National Natural Science Foundation of China (NSFC 31101269), China Postdoctoral Science special Foundation (2013T60648), National Science & Technology Pillar Program during the Twelfth Five-year Plan Period (2012BAD36B05), the Second Class General Financial Grant from the China Postdoctoral Science Foundation (Grant No. 2012M511702) and 2012 Excellent Key Young Teachers Project of Jiangsu University.  The related results have been published in peer-reviewed journals including Journal of Agricultural and Food Chemistry, Process Biochemistry, International Journal of Biological Macromolecules, Drying Technology, Bioresource Technology and Toxicology in vitro.

 

(School of Food and Biological Engineering)

¡¼Returns¡½ Hits£º425 Date£º2015-6-23
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